Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.56 |
| ▸ | ALPL | P05186 | 3/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13615358 | 0.82 | CHEK1 (0.46) | SMN1; SMN2ALPLALDH1A1KDM4EHPGD | |
| SCHEMBL22637413 | 0.81 | CA12 (0.46) | SMN1; SMN2HTTMAPK10ALPLMAPT | |
| SCHEMBL29408161 | 0.79 | PRKAG1 (0.54) | SMN1; SMN2HTTMAPK10ALPLCA9 | |
| SCHEMBL8890557 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2HTTMAPK10ALPLCA9 | |
| SCHEMBL4711570 | 0.75 | KDM4E (0.47) | SMN1; SMN2HTTMAPK10ALPLALDH1A1 | |
| SCHEMBL29408204 | 0.75 | PRKAG1 (0.56) | SMN1; SMN2HTTMAPK10ALPLCA9 | |
| SCHEMBL8887137 | 0.74 | CDK4 (0.52) | SMN1; SMN2HTTMAPK10ALDH1A1KDM4E | |
| SCHEMBL4710473 | 0.74 | SMN1; SMN2 (0.51) | SMN1; SMN2HTTMAPK10ALPLALDH1A1 | |
| SCHEMBL12273602 | 0.74 | CA12 (0.47) | SMN1; SMN2ALPLCA9ALDH1A1KDM4E | |
| SCHEMBL4712758 | 0.73 | SMN1; SMN2 (0.57) | SMN1; SMN2HTTHPGDRXFP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | disclosed |