Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | F10 | P00742 | 4/20 | 0.34 |
| ▸ | PLK1 | P53350 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.34 |
| ▸ | CYBB | P04839 | 2/20 | 0.33 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.31 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.30 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.30 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.30 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | POLQ | O75417 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4721104 | 0.95 | PLK1 (0.35) | PDE4APDE4BPDE4CPDE4DF10 | |
| SCHEMBL4720930 | 0.92 | PDE4A (0.36) | PDE4APDE4BPDE4CPDE4DF10 | |
| SCHEMBL4720189 | 0.91 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DF10 | |
| SCHEMBL4721033 | 0.89 | F10 (0.39) | PDE4APDE4BPDE4CPDE4DF10 | |
| SCHEMBL4720453 | 0.86 | F10 (0.43) | PDE4APDE4BPDE4CPDE4DF10 | |
| SCHEMBL4719129 | 0.84 | HRH3 (0.40) | PDE4APDE4BPDE4CPDE4DF10 | |
| SCHEMBL4719466 | 0.84 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DF10 | |
| SCHEMBL4721150 | 0.84 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DF10 | |
| SCHEMBL4723846 | 0.83 | PDE4B (0.38) | PDE4APDE4BPDE4CPDE4DF10 | |
| SCHEMBL4718698 | 0.83 | HRH3 (0.41) | PDE4APDE4BPDE4CPDE4DHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |