Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.51 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.39 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772225 | 0.93 | TAAR1 (0.47) | TAAR1P2RX3P2RX2GAAMAPT | |
| SCHEMBL1579468 | 0.87 | KDM4E (0.42) | TAAR1GAAMAPTTSHRMAPK1 | |
| SCHEMBL7256087 | 0.82 | GAA (0.46) | TAAR1GAAMAPTTSHRMAPK1 | |
| SCHEMBL577652 | 0.81 | GAA (0.55) | TAAR1GAAMAPTMAPK1RAB9A | |
| SCHEMBL4768439 | 0.81 | TAAR1 (0.39) | TAAR1MAPK1HTTHTR2ARAB9A | |
| SCHEMBL21798818 | 0.81 | TAAR1 (0.45) | TAAR1GAAMAPTTSHRMAPK1 | |
| SCHEMBL4847393 | 0.79 | TAAR1 (0.47) | TAAR1P2RX3P2RX2MAPTTSHR | |
| SCHEMBL5951991 | 0.79 | TAAR1 (0.59) | TAAR1P2RX3P2RX2GAAMAPT | |
| SCHEMBL27749404 | 0.79 | ALDH1A1 (0.32) | — | |
| SCHEMBL17653319 | 0.78 | HTR2A (0.44) | TAAR1MAPTHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989195-A1 | PHOSPHODIESTERASE 10 INHIBITORS | Amgen Inc. (US) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007103260-A1 | PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2007-09-13 | — | — | WO | disclosed |