Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 4/20 | 0.34 |
| ▸ | HTR2C | P28335 | 4/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1579468 | 0.86 | KDM4E (0.42) | TAAR1ALDH1A1HTR2AMAPK1HTT | |
| SCHEMBL875687 | 0.83 | HMGCR (0.44) | ALDH1A1MEN1POLBHPGDKMT2A | |
| SCHEMBL24839269 | 0.82 | TAAR1 (0.52) | TAAR1HTR2AHTR2CHTR2BLMNA | |
| SCHEMBL4765824 | 0.81 | TAAR1 (0.51) | TAAR1HTR2AMAPK1HTTRAB9A | |
| SCHEMBL577652 | 0.80 | GAA (0.55) | TAAR1ALDH1A1HPGDMAPK1RAB9A | |
| SCHEMBL7003415 | 0.79 | MTNR1A (0.44) | TAAR1ALDH1A1MEN1POLBHPGD | |
| SCHEMBL4772225 | 0.78 | TAAR1 (0.47) | TAAR1ALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL17653319 | 0.77 | HTR2A (0.44) | TAAR1POLBHTR2AHTR2C | |
| SCHEMBL21798818 | 0.76 | TAAR1 (0.45) | TAAR1ALDH1A1MEN1KMT2AHTR2A | |
| SCHEMBL30536200 | 0.75 | HTR2A (0.39) | TAAR1ALDH1A1MEN1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989195-A1 | PHOSPHODIESTERASE 10 INHIBITORS | Amgen Inc. (US) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007103260-A1 | PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2007-09-13 | — | — | WO | disclosed |