SCHEMBL4765889

SCHEMBL4765889

NC(=O)C(=O)c1cccs1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.74
CES1 P23141 2/20 0.74
DAO P14920 1/20 0.58
KMT2A Q03164 4/20 0.54
NPC1 O15118 4/20 0.54
RAB9A P51151 4/20 0.54
MEN1 O00255 3/20 0.54
LMNA P02545 3/20 0.54
ALDH1A1 P00352 2/20 0.54
POLB P06746 1/20 0.54
HDAC1 Q13547 1/20 0.54
HPGD P15428 3/20 0.50
HPGDS O60760 1/20 0.50
GSK3B P49841 1/20 0.50
HTT P42858 1/20 0.50
TDP1 Q9NUW8 1/20 0.48
SMN1; SMN2 Q16637 2/20 0.46
MAPK10 P53779 1/20 0.46
PKM P14618 1/20 0.46
MAPT P10636 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1066873 0.85 CES2 (1.00) CES2CES1DAOKMT2ANPC1
SCHEMBL9148741 0.81 CES2 (0.81) CES2CES1DAOKMT2ANPC1
SCHEMBL120212 0.81
SCHEMBL937615 0.81
Hydrochloric Acid SCHEMBL485645 0.79
SCHEMBL71555 0.79 CES2 (0.77) CES2CES1DAOKMT2ANPC1
Urea SCHEMBL4239865 0.79 CES2 (0.62) CES2CES1DAOKMT2ANPC1
Hydrochloric Acid SCHEMBL3194035 0.79 CES2 (0.62) CES2CES1DAOKMT2ANPC1
SCHEMBL1379741 0.78 CES2 (0.56) CES2CES1DAOKMT2ANPC1
SCHEMBL1883541 0.77 CES2 (0.74) CES2CES1DAOKMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2764034-B1 POLYMERS BASED ON BENZODIONES CLAP CO LTD (KR) 2023-08-30 EP disclosed
CN-114502543-A Targeted protein compounds, pharmaceutical compositions and therapeutic applications thereof 拜欧斯瑞克斯公司 2022-05-13 CN disclosed
EP-3019196-B1 COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2018-06-06 EP disclosed
US-9240551-B2 Polymers based on benzodiones BASF SE (DE) 2016-01-19 US disclosed
US-9240551-B2 Polymers based on benzodiones BASF SE (DE) 2016-01-19 US disclosed
US-20140302637-A1 POLYMERS BASED ON BENZODIONES BASF SE (DE) 2014-10-09 US disclosed
US-20140302637-A1 POLYMERS BASED ON BENZODIONES BASF SE (DE) 2014-10-09 US disclosed
WO-2013050401-A2 POLYMERS BASED ON BENZODIONES BASF SE (DE) 2013-04-11 WO disclosed
EP-1636217-B1 2-IMIDAZO-BENZOTHIAZOLES AS ADENOSINE RECEPTOR LIGANDS HOFFMANN LA ROCHE (CH) 2008-09-03 EP disclosed
EP-1450796-B1 BENZOTHIAZOLE DERIVATIVES HOFFMANN LA ROCHE (CH) 2008-04-09 EP disclosed
US-20030069294-A1 Alpha-substituted carboxylic acid derivatives SANKYO COMPANY, LIMITED (JP) 2003-04-10 US disclosed
WO-2002050091-A1 MACROLIDE ANTIBIOTICS GLAXO GROUP LIMITED (GB) 2002-06-27 WO disclosed
EP-1167357-A1 ALPHA-SUBSTITUTED CARBOXYLIC ACID DERIVATIVES Sankyo Company, Limited (JP) 2002-01-02 EP disclosed
EP-0387677-B1 Thienylacetic acid derivatives, process for their preparation, their application as well as pharmaceuticals containing them and their preparation CASSELLA FARBWERKE MAINKUR AG (DE) 1994-03-16 EP disclosed
EP-0388750-B1 Thienyl piperazines, process for their preparation, their use, pharmaceutical agents containing them and their production CASSELLA FARBWERKE MAINKUR AG (DE) 1994-01-26 EP disclosed
US-5015659-A Cognition activators to slow aging of the brain CASSELLA AKTIENGESELLSCHAFT (DE) 1991-05-14 US disclosed
US-4987134-A DISORDERS OF BRAIN FUNCTIONS CASSELLA AKTIENGESELLSCHAFT (DE) 1991-01-22 US disclosed
EP-0388750-A1 Thienyl piperazines, process for their preparation, their use, pharmaceutical agents containing them and their production CASSELLA Aktiengesellschaft (DE) 1990-09-26 EP disclosed
EP-0387677-A2 Thienylacetic acid derivatives, process for their preparation, their application as well as pharmaceuticals containing them and their preparation CASSELLA Aktiengesellschaft (DE) 1990-09-19 EP disclosed
US-4118298-A PHOTOINITIATOR STAUFFER CHEMICAL COMPANY (US) 1978-10-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030069294-A1 Alpha-substituted carboxylic acid derivatives SLC5A1, SLC2A1, GPR119 CES2 718/4885CES1 33/4885DAO 168/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.