Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.41 |
| ▸ | PGK1 | P00558 | 3/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | STK17B | O94768 | 1/20 | 0.34 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4766397 | 0.88 | CSNK1A1 (0.51) | CSNK1A1CLK4PIN1PGK1LRRK2 | |
| SCHEMBL4770518 | 0.87 | CSNK1A1 (0.47) | CSNK1A1CLK4PIN1PGK1LRRK2 | |
| SCHEMBL2446241 | 0.83 | STK17A (0.47) | CSNK1A1CLK4PGK1CDK1CDK2 | |
| SCHEMBL4768126 | 0.83 | CNR1 (0.46) | CSNK1A1CLK4PIN1PGK1LRRK2 | |
| SCHEMBL4768640 | 0.81 | POLB (0.49) | CSNK1A1CLK4PIN1PGK1LRRK2 | |
| SCHEMBL4773544 | 0.81 | CSNK1A1 (0.55) | CSNK1A1CLK4PIN1PGK1LRRK2 | |
| SCHEMBL4772159 | 0.81 | CSNK1A1 (0.47) | CSNK1A1CLK4PIN1PGK1LRRK2 | |
| SCHEMBL27502303 | 0.81 | CSNK1A1 (0.51) | CSNK1A1CLK4PIN1CDK2ALDH1A1 | |
| SCHEMBL4763576 | 0.80 | CSNK1A1 (0.44) | CSNK1A1CLK4PIN1PGK1LRRK2 | |
| SCHEMBL4765379 | 0.80 | CSNK1A1 (0.44) | CSNK1A1CLK4PIN1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| US-6908920-B2 | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2005-06-21 | — | — | US | disclosed |