Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | MBOAT4 | Q96T53 | 3/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PGK1 | P00558 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | STK17B | O94768 | 1/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27502303 | 0.84 | CSNK1A1 (0.51) | CSNK1A1CLK4PIN1ALDH1A1EGFR | |
| SCHEMBL4766397 | 0.82 | CSNK1A1 (0.51) | CSNK1A1CLK4PIN1ALDH1A1L3MBTL1 | |
| SCHEMBL22997993 | 0.82 | CSNK1A1 (0.45) | CSNK1A1CLK4PIN1ALDH1A1EGFR | |
| SCHEMBL4768640 | 0.82 | POLB (0.49) | CSNK1A1CLK4PIN1ALDH1A1L3MBTL1 | |
| SCHEMBL4765894 | 0.81 | CSNK1A1 (0.50) | CSNK1A1CLK4PIN1ALDH1A1L3MBTL1 | |
| SCHEMBL4579364 | 0.81 | SMN1; SMN2 (0.45) | CSNK1A1CLK4PIN1ALDH1A1NPC1 | |
| SCHEMBL4765379 | 0.81 | CSNK1A1 (0.44) | CSNK1A1CLK4PIN1ALDH1A1L3MBTL1 | |
| SCHEMBL4766382 | 0.80 | CSNK1A1 (0.46) | CSNK1A1CLK4MBOAT4PIN1ALDH1A1 | |
| SCHEMBL4770518 | 0.78 | CSNK1A1 (0.47) | CSNK1A1CLK4PIN1ALDH1A1L3MBTL1 | |
| SCHEMBL4768126 | 0.77 | CNR1 (0.46) | CSNK1A1CLK4PIN1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |