Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768096 | 0.79 | HRH3 (0.56) | HRH3CYP2D6HRH1 | |
| SCHEMBL4793933 | 0.78 | HRH3 (0.51) | HRH3CYP2D6KDM2B | |
| SCHEMBL4792086 | 0.78 | FKBP1A (0.45) | HRH3CYP2D6HRH1 | |
| SCHEMBL4791232 | 0.77 | HRH3 (0.44) | HRH3CYP2D6HRH1 | |
| SCHEMBL4792011 | 0.76 | HRH3 (0.42) | HRH3CYP2D6HRH1 | |
| SCHEMBL4777033 | 0.75 | HRH3 (0.39) | HRH3CYP2D6HRH1 | |
| SCHEMBL4793850 | 0.75 | HRH3 (0.45) | HRH3MCHR1KDM2B | |
| SCHEMBL4791446 | 0.73 | HRH3 (0.43) | HRH3MCHR1CYP2D6KDM2B | |
| SCHEMBL4775079 | 0.72 | MEN1 (0.52) | HRH3ALDH1A1MEN1KMT2AMCHR1 | |
| SCHEMBL4793665 | 0.72 | MEN1 (0.43) | HRH3ALDH1A1MEN1KMT2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |