Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 7/20 | 0.34 |
| ▸ | KDM5A | P29375 | 6/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.34 |
| ▸ | RET | P07949 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 9/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.33 |
| ▸ | FLT1 | P17948 | 2/20 | 0.33 |
| ▸ | FLT4 | P35916 | 2/20 | 0.33 |
| ▸ | KDM4A | O75164 | 2/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4771434 | 0.81 | EGFR (0.37) | RETKDRFGFR1KITPDGFRA | |
| SCHEMBL4283173 | 0.80 | KDR (0.39) | KDM4CKDM5AKDM5BRETKDR | |
| SCHEMBL4284961 | 0.78 | KDR (0.61) | KDRFGFR1KITPDGFRAFLT1 | |
| SCHEMBL4278148 | 0.75 | RET (0.36) | RETKDRFGFR1KITPDGFRA | |
| SCHEMBL4282301 | 0.75 | EGFR (0.41) | RETKDR | |
| SCHEMBL4771430 | 0.74 | EGFR (0.37) | RETKDRFGFR1KITPDGFRA | |
| SCHEMBL4290591 | 0.68 | DYRK1A (0.45) | KDR | |
| SCHEMBL14674224 | 0.67 | SOS1 (0.45) | — | |
| SCHEMBL501648 | 0.66 | KCNQ3 (0.34) | — | |
| SCHEMBL14674398 | 0.65 | HTR2A (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904498-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007004749-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-11 | — | — | WO | disclosed |