Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 14/20 | 0.36 |
| ▸ | RET | P07949 | 3/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | FLT1 | P17948 | 1/20 | 0.31 |
| ▸ | FLT4 | P35916 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4282301 | 0.82 | EGFR (0.41) | EGFRKDRRETLCK | |
| SCHEMBL4771434 | 0.80 | EGFR (0.37) | EGFRKDRRETFGFR1CSF1R | |
| SCHEMBL4290591 | 0.74 | DYRK1A (0.45) | EGFRKDR | |
| SCHEMBL4766245 | 0.74 | KDM4C (0.34) | KDRRETFGFR1CSF1RKIT | |
| SCHEMBL4283173 | 0.71 | KDR (0.39) | EGFRKDRRETCSF1RKIT | |
| SCHEMBL15960748 | 0.69 | KDR (0.53) | EGFRKDRRETLCKKIT | |
| SCHEMBL4284980 | 0.69 | KDR (0.56) | KDRFGFR1 | |
| SCHEMBL4668514 | 0.68 | KDR (0.74) | EGFRKDRRETLCKCSF1R | |
| SCHEMBL31616965 | 0.68 | KDR (0.74) | EGFRKDRRETLCKCSF1R | |
| SCHEMBL3573516 | 0.67 | AXL (0.45) | EGFRKDRLCKKITPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904498-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007004749-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-11 | — | — | WO | disclosed |