Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4766270 | 1.00 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL4765296 | 0.89 | NPC1 (0.40) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL4765284 | 0.89 | NPC1 (0.40) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL4762617 | 0.87 | NPC1 (0.41) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL4762612 | 0.87 | NPC1 (0.41) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL4763471 | 0.87 | NCOA1 (0.42) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL4763478 | 0.87 | NCOA1 (0.42) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL4769555 | 0.83 | NPC1 (0.41) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL4769549 | 0.83 | NPC1 (0.41) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL4769133 | 0.83 | MAPT (0.46) | SMN1; SMN2MAPTALDH1A1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678181-B1 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2008-12-31 | — | — | EP | disclosed |