Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3994387 | 0.86 | NR3C1 (0.33) | SYKPOLBAPEX1LMNAMAPT | |
| SCHEMBL3988963 | 0.73 | MEN1 (0.36) | POLBLMNASMN1; SMN2 | |
| SCHEMBL12697387 | 0.71 | POLB (0.45) | SYKPOLBAPEX1LMNAMAPT | |
| SCHEMBL3988980 | 0.71 | CNR1 (0.39) | POLBLMNASMN1; SMN2 | |
| SCHEMBL3989920 | 0.69 | ACACB (0.42) | LMNAMAPT | |
| SCHEMBL5138223 | 0.68 | CNR2 (0.40) | LMNA | |
| SCHEMBL4775541 | 0.67 | USP30 (0.35) | POLB | |
| SCHEMBL13065416 | 0.67 | SYK (0.48) | SYKPOLBAPEX1SMN1; SMN2 | |
| SCHEMBL1035202 | 0.66 | POLB (0.49) | SYKPOLBAPEX1MAPTSMN1; SMN2 | |
| SCHEMBL4768472 | 0.66 | NFKB1 (0.52) | SYKPOLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753764-B1 | PYRROLOPYRIDINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2008-10-29 | — | — | EP | disclosed |
| EP-1753764-A1 | PYRROLOPYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005121140-A1 | PYRROLOPYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2005-12-22 | — | — | WO | disclosed |