Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 3/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4638046 | 0.87 | PTGDR2 (0.47) | KCNQ3KCNQ2PTGDR2EPAS1SLC6A9 | |
| SCHEMBL586124 | 0.81 | PTGDR2 (0.47) | KCNQ3KCNQ2PTGDR2PTGS2 | |
| SCHEMBL27746551 | 0.77 | PTGDR2 (0.42) | PTGDR2POLBMAPTPKMBRD4 | |
| SCHEMBL883916 | 0.76 | MAPT (0.44) | PTGDR2POLBMAPTPKMEPAS1 | |
| SCHEMBL585822 | 0.76 | KCNQ3 (0.41) | KCNQ3KCNQ2PTGDR2SLC6A9KCNH2 | |
| SCHEMBL10884180 | 0.74 | EPAS1 (0.46) | PTGDR2CYP11B1CYP11B2EPAS1PTGS2 | |
| SCHEMBL585259 | 0.74 | KCNQ3 (0.41) | KCNQ3KCNQ2PTGDR2SLC6A9KCNH2 | |
| SCHEMBL28826122 | 0.73 | KIF11 (0.42) | PTGDR2SLC6A9BRD4ABCB11ALOX5AP | |
| SCHEMBL4766608 | 0.73 | SLC22A12 (0.46) | POLBMAPTPKMEPAS1 | |
| SCHEMBL4637384 | 0.73 | BRD4 (0.35) | POLBEPAS1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963259-A2 | SUBSTITUTED DIPHENYLETHERS, -AMINES, -SULFIDES AND -METHANES FOR THE TREATMENT OF RESPIRATORY DISEASE | AstraZeneca AB (SE) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007068894-A2 | SUBSTITUTED DIPHENYLETHERS, -AMINES, -SULFIDES AND -METHANES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |