Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 5/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4142012 | 0.87 | PDK1 (0.43) | S1PR1HRH3OPRD1HTR2CHTR2A | |
| SCHEMBL4140818 | 0.85 | MCHR1 (0.39) | S1PR1OPRD1TRPA1HTR2CHTR2A | |
| SCHEMBL4127461 | 0.84 | HTR2C (0.51) | HRH3HTR2CHTR2A | |
| SCHEMBL4127329 | 0.84 | HTR1A (0.42) | HRH3OPRD1HTR2CHTR2A | |
| SCHEMBL4148990 | 0.84 | HRH3 (0.36) | HRH3HCRTR1HTR2CHTR2A | |
| SCHEMBL4140975 | 0.84 | USP30 (0.45) | HRH3SCN9A | |
| SCHEMBL4141684 | 0.83 | BACE1 (0.37) | S1PR1HRH3HTR2C | |
| SCHEMBL4135556 | 0.83 | CD274 (0.38) | HRH3OPRD1HTR2CHTR2A | |
| SCHEMBL4136060 | 0.82 | HRH3 (0.43) | HRH3HTR2CHTR2A | |
| SCHEMBL4128118 | 0.82 | PDK1 (0.42) | HRH3OPRD1HTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007749-A2 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | Pfizer Products Inc. (US) | 2008-12-31 | — | — | EP | claimed |
| WO-2007105053-A2 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-09-20 | — | — | WO | claimed |