Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11261036 | 0.71 | CYP2C19 (0.35) | POLBTDP1CYP2C19MAPTHTT | |
| SCHEMBL11261034 | 0.71 | CYP2C19 (0.35) | POLBTDP1CYP2C19MAPTHTT | |
| SCHEMBL9169336 | 0.70 | HTT (0.35) | CYP2C19MAPTCACNA1BAPBA1HTT | |
| SCHEMBL8586862 | 0.70 | CYP2C19 (0.37) | POLBTDP1CYP2C19MAPTHTT | |
| SCHEMBL27412775 | 0.69 | MAPT (0.41) | POLBTDP1CYP2C19MAPTHTT | |
| SCHEMBL1361079 | 0.69 | CYP2C19 (0.39) | POLBTDP1CYP2C19MAPT | |
| SCHEMBL770755 | 0.69 | CYP2C19 (0.39) | POLBTDP1CYP2C19MAPT | |
| SCHEMBL2302989 | 0.68 | CYP2C19 (0.36) | POLBTDP1CYP2C19MAPTHTT | |
| SCHEMBL11740552 | 0.68 | MAPT (0.39) | POLBTDP1CYP2C19MAPT | |
| SCHEMBL7275682 | 0.68 | CYP2C19 (0.36) | POLBTDP1CYP2C19MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613606-A4 | METHODS FOR PREPARING 2,3,5,6-SUBSTITUTED 3H-PYRIMIDIN-4-ONES | NPS PHARMA INC (US) | 2008-12-03 | — | — | EP | disclosed |
| EP-1613606-A2 | METHODS FOR PREPARING 2,3,5,6-SUBSTITUTED 3H-PYRIMIDIN-4-ONES | NPS PHARMACEUTICALS, INC. (US) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004092121-A2 | METHODS FOR PREPARING 2,3,5,6-SUBSTITUTED 3H-PYRIMIDIN-4-ONES | NPS PHARMACEUTICALS, INC. (US) | 2004-10-28 | — | — | WO | disclosed |