Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL354285 | 0.91 | CYP2C19 (0.37) | CYP2C19POLBTDP1ALDH1A1LMNA | |
| SCHEMBL7433180 | 0.89 | CYP2C19 (0.36) | CYP2C19POLBTDP1ALDH1A1LMNA | |
| SCHEMBL7445820 | 0.82 | POLB (0.35) | CYP2C19POLBTDP1ALDH1A1LMNA | |
| SCHEMBL5879371 | 0.81 | ZDHHC20 (0.40) | CYP2C19POLBLMNAMAPTTSHR | |
| SCHEMBL770755 | 0.81 | CYP2C19 (0.39) | CYP2C19POLBTDP1ALDH1A1LMNA | |
| SCHEMBL27412775 | 0.81 | MAPT (0.41) | CYP2C19POLBTDP1ALDH1A1LMNA | |
| Ammonia Solution, Strong SCHEMBL16982684 | 0.79 | MAPT (0.40) | CYP2C19POLBTDP1ALDH1A1LMNA | |
| SCHEMBL3181055 | 0.79 | CYP2C19 (0.38) | CYP2C19POLBTDP1ALDH1A1LMNA | |
| SCHEMBL2053110 | 0.79 | CYP2C19 (0.38) | CYP2C19POLBTDP1ALDH1A1LMNA | |
| SCHEMBL631049 | 0.79 | CYP2C19 (0.38) | CYP2C19POLBTDP1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080227989-A1 | Methyl 2,4,9-trithiaadamantane-7-carboxylate | UNIVERSITY OF AKRON, THE | 2008-09-18 | — | — | US | claimed |
| EP-1740592-A4 | METHYL 2,4,9-TRITHIAADAMANTANE-7-CARBOXYLATE | UNIV AKRON (US) | 2008-03-26 | — | — | EP | claimed |
| US-7348441-B2 | Methyl 2,4,9-trithiaadamantane-7-carboxylate | THE UNIVERSITY OF AKRON (US) | 2008-03-25 | — | — | US | claimed |
| US-20070173650-A1 | Methyl 2,4,9-trithiaadamantane-7-carboxylate | UNIVERSITY OF AKRON | 2007-07-26 | — | — | US | claimed |
| EP-1740592-A2 | METHYL 2,4,9-TRITHIAADAMANTANE-7-CARBOXYLATE | THE UNIVERSITY OF AKRON (US) | 2007-01-10 | — | — | EP | claimed |
| WO-2005120186-A2 | METHYL 2,4,9-TRITHIAADAMANTANE-7-CARBOXYLATE | THE UNIVERSITY OF AKRON (US) | 2005-12-22 | — | — | WO | claimed |
| US-8066914-B2 | 7-ethynyl-2,4,9-trithiaadamantane and related methods | UNIVERSITY OF AKRON (US) | 2011-11-29 | — | — | US | disclosed |
| US-8066914-B2 | 7-ethynyl-2,4,9-trithiaadamantane and related methods | UNIVERSITY OF AKRON (US) | 2011-11-29 | — | — | US | disclosed |
| US-8066914-B2 | 7-ethynyl-2,4,9-trithiaadamantane and related methods | UNIVERSITY OF AKRON (US) | 2011-11-29 | — | — | US | disclosed |
| US-20100072425-A1 | 7-ETHYNYL-2,4,9-TRITHIAADAMANTANE AND RELATED METHODS | THE UNIVERSITY OF AKRON (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100072425-A1 | 7-ETHYNYL-2,4,9-TRITHIAADAMANTANE AND RELATED METHODS | THE UNIVERSITY OF AKRON (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100072425-A1 | 7-ETHYNYL-2,4,9-TRITHIAADAMANTANE AND RELATED METHODS | THE UNIVERSITY OF AKRON (US) | 2010-03-25 | — | — | US | disclosed |
| US-7501529-B2 | 7-Ethynyl-2,4,9-trithiaadamantane and related methods | THE UNIVERSITY OF AKRON (US) | 2009-03-10 | — | — | US | disclosed |
| US-20070173650-A1 | Methyl 2,4,9-trithiaadamantane-7-carboxylate | UNIVERSITY OF AKRON | 2007-07-26 | — | — | US | disclosed |
| US-20070173650-A1 | Methyl 2,4,9-trithiaadamantane-7-carboxylate | UNIVERSITY OF AKRON | 2007-07-26 | — | — | US | disclosed |
| EP-1740592-A2 | METHYL 2,4,9-TRITHIAADAMANTANE-7-CARBOXYLATE | THE UNIVERSITY OF AKRON (US) | 2007-01-10 | — | — | EP | disclosed |
| EP-1740592-A2 | METHYL 2,4,9-TRITHIAADAMANTANE-7-CARBOXYLATE | THE UNIVERSITY OF AKRON (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005120186-A2 | METHYL 2,4,9-TRITHIAADAMANTANE-7-CARBOXYLATE | THE UNIVERSITY OF AKRON (US) | 2005-12-22 | — | — | WO | disclosed |
| WO-2005120186-A2 | METHYL 2,4,9-TRITHIAADAMANTANE-7-CARBOXYLATE | THE UNIVERSITY OF AKRON (US) | 2005-12-22 | — | — | WO | disclosed |
| WO-2005003089-A2 | 7-ETHYNYL-2,4,9-TRITHIAADAMANTANE AND RELATED METHODS | THE UNIVERSITY OF AKRON (US) | 2005-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080227989-A1 | Methyl 2,4,9-trithiaadamantane-7-carboxylate | TST, TPMT, MGMT | CYP2C19 3515/4885POLB 3328/4885TDP1 2284/4885 |
| US-20100072425-A1 | 7-ETHYNYL-2,4,9-TRITHIAADAMANTANE AND RELATED METHODS | ALKBH2, AOX1, TET1 | CYP2C19 1550/4885POLB 1445/4885TDP1 494/4885 |
| US-20070173650-A1 | Methyl 2,4,9-trithiaadamantane-7-carboxylate | TST, TPMT, MGMT | CYP2C19 3515/4885POLB 3328/4885TDP1 2284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.