Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 3/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29529775 | 0.88 | FFAR1 (0.44) | FFAR1HTTALDH1A1MAPTHPGD | |
| SCHEMBL25321453 | 0.88 | FFAR1 (0.44) | FFAR1HTTALDH1A1MAPTHPGD | |
| SCHEMBL25321602 | 0.85 | CLK1 (0.38) | FFAR1HTTGRM5SYKALDH1A1 | |
| SCHEMBL25319653 | 0.84 | HTT (0.39) | FFAR1HTTALDH1A1SMN1; SMN2PIP4K2A | |
| SCHEMBL25323757 | 0.84 | HTT (0.37) | FFAR1HTTALDH1A1SMN1; SMN2PIP4K2A | |
| SCHEMBL29530232 | 0.84 | HTT (0.37) | FFAR1HTTALDH1A1SMN1; SMN2PIP4K2A | |
| SCHEMBL25320336 | 0.80 | IDH1 (0.39) | FFAR1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL29530250 | 0.78 | ALDH1A1 (0.38) | FFAR1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL25320659 | 0.78 | ALDH1A1 (0.38) | FFAR1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL4544596 | 0.75 | FNTA (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004667-A2 | NOVEL 11 BETA - HYDROXYANDROSTA-4-ENE-3-ONES | Sun Pharma Advanced Research Company Limited (IN) | 2008-12-24 | — | — | EP | claimed |
| WO-2007099548-A2 | NOVEL 11 BETA - HYDROXYANDROSTA-4-ENE-3-ONES | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2007-09-07 | — | — | WO | claimed |
| EP-1934228-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007027855-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-03-08 | — | — | WO | disclosed |
| US-20070049603-A1 | Raf inhibitor compounds and methods of use thereof | ARRAY BIOPHARMA INC. | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049603-A1 | Raf inhibitor compounds and methods of use thereof | BRAF, RAF1, ARAF | FFAR1 2178/4885GABRA1 3660/4885GABRG2 3437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.