Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC8 | Q09428 | 1/20 | 0.48 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CLK1 | P49759 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4115923 | 0.81 | DYRK1A (0.44) | ABCC8KCNJ11DYRK1AMAPTALDH1A1 | |
| SCHEMBL29945802 | 0.79 | PDE3B (0.38) | ABCC8KCNJ11MAPTALDH1A1KDM4E | |
| SCHEMBL4724370 | 0.77 | SMN1; SMN2 (0.46) | DYRK1AMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL26433546 | 0.73 | ALDH1A1 (0.43) | DYRK1AMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL30014143 | 0.72 | KDM4E (0.62) | MAPTALDH1A1KDM4ENPSR1CYP3A4 | |
| SCHEMBL24393123 | 0.72 | DYRK1A (0.44) | ABCC8KCNJ11DYRK1AMAPTALDH1A1 | |
| SCHEMBL4134456 | 0.70 | PIK3CA (0.47) | ABCC8KCNJ11DYRK1AMAPTALDH1A1 | |
| SCHEMBL24392637 | 0.69 | DYRK1A (0.41) | ABCC8KCNJ11DYRK1AMAPTALDH1A1 | |
| SCHEMBL24391802 | 0.69 | DYRK1A (0.41) | ABCC8KCNJ11DYRK1AMAPTALDH1A1 | |
| SCHEMBL12348055 | 0.67 | DYRK1A (0.55) | ABCC8KCNJ11DYRK1AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940823-A2 | SUBSTITUTED 1-AMINO-PHTHALZINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007042660-A2 | SUBSTITUTED 1-AMINO-PHTHALZINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2007-04-19 | — | — | WO | disclosed |