Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 10/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 10/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 5/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | TGM2 | P21980 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4767454 | 1.00 | ITGB3 (0.47) | ITGB3ITGA2BTSHRCTSKCTSL | |
| SCHEMBL27469415 | 0.87 | CTSK (0.52) | ITGB3ITGA2BTSHRCTSKCTSL | |
| SCHEMBL4916101 | 0.86 | ITGB3 (0.50) | ITGB3ITGA2BTSHRCTSKCTSL | |
| SCHEMBL4916104 | 0.86 | ITGB3 (0.50) | ITGB3ITGA2BTSHRCTSKCTSL | |
| SCHEMBL7453518 | 0.85 | TSHR (0.49) | ITGB3ITGA2BTSHRCTSKCTSS | |
| SCHEMBL9103036 | 0.84 | CTSK (0.52) | ITGB3ITGA2BTSHRCTSKCTSS | |
| SCHEMBL9103039 | 0.84 | CTSK (0.52) | ITGB3ITGA2BTSHRCTSKCTSS | |
| SCHEMBL23845159 | 0.84 | HRH2 (0.48) | ITGB3ITGA2BTSHRCTSKCTSL | |
| SCHEMBL1706617 | 0.84 | CTSK (0.54) | ITGB3ITGA2BTSHRCTSKCTSL | |
| SCHEMBL1707105 | 0.84 | CTSK (0.54) | ITGB3ITGA2BTSHRCTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572678-A4 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | ELAN PHARM INC (US) | 2008-05-07 | — | — | EP | claimed |
| EP-1572678-A2 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | Elan Pharmaceuticals, Inc. (US) | 2005-09-14 | — | — | EP | claimed |
| EP-1501807-A1 | SULFONYLQUINOXALONE ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ ANTAGONISTS | Elan Pharmaceuticals, Inc. (US) | 2005-02-02 | — | — | EP | claimed |
| WO-2004056319-A2 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | ELAN PHARMACEUTICALS INC. (US) | 2004-07-08 | — | — | WO | claimed |
| WO-2003093245-A1 | SULFONYLQUINOXALONE ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ ANTAGONISTS | ELAN PHARMACEUTICALS, INC. (US) | 2003-11-13 | — | — | WO | claimed |