Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 3/20 | 0.41 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | TAS2R14 | Q9NYV8 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3579784 | 0.92 | MAPT (0.51) | MAPTKDM4E | |
| SCHEMBL4765213 | 0.82 | KDM4E (0.45) | MAPTDPP4KDM4EPPARG | |
| SCHEMBL3569292 | 0.79 | KDM4E (0.58) | L3MBTL1KDM4EPPARG | |
| SCHEMBL2381071 | 0.78 | KDM4E (0.44) | MAPTKDM4E | |
| SCHEMBL4762397 | 0.77 | KDM4E (0.46) | MAPTKDM4EPPARG | |
| SCHEMBL2384414 | 0.76 | PADI4 (0.44) | MAPTL3MBTL1KDM4E | |
| SCHEMBL4766131 | 0.76 | HRH3 (0.43) | KDM4EPPARG | |
| SCHEMBL3564918 | 0.75 | LOXL2 (0.47) | MAPTL3MBTL1PPARG | |
| SCHEMBL3867031 | 0.73 | KDM4E (0.51) | MAPTL3MBTL1KDM4E | |
| SCHEMBL1338964 | 0.72 | GSK3B (0.41) | KDM4EPPARGCXCR3PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742947-B1 | 6-SUBSTITUTED PYRIDOINDOLONE DERIVATIVES PRODUCTION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2008-08-20 | — | — | EP | disclosed |
| EP-1742947-A1 | 6-SUBSTITUTED PYRIDOINDOLONE DERIVATIVES PRODUCTION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005108398-A1 | 6-SUBSTITUTED PYRIDOINDOLONE DERIVATIVES PRODUCTION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2005-11-17 | — | — | WO | disclosed |