Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 3/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | RARB | P10826 | 1/20 | 0.34 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.34 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3564918 | 0.88 | LOXL2 (0.47) | PPARGALDH1A1HPGDMAPTPTGER4 | |
| SCHEMBL3569292 | 0.86 | KDM4E (0.58) | KDM4EPPARGALDH1A1HPGDHSD17B10 | |
| SCHEMBL2385861 | 0.84 | KDM4E (0.41) | KDM4EALDH1A1MAPT | |
| SCHEMBL4762397 | 0.83 | KDM4E (0.46) | KDM4EPPARGALDH1A1HPGDMAPT | |
| SCHEMBL4767544 | 0.82 | MEP1B (0.41) | KDM4EPPARGMAPTDPP4 | |
| SCHEMBL4766131 | 0.82 | HRH3 (0.43) | KDM4EPPARGALDH1A1HPGDPTGER4 | |
| SCHEMBL3571739 | 0.79 | KDM4E (0.43) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL1338146 | 0.76 | MEN1 (0.39) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL1339208 | 0.76 | KDM4E (0.42) | KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL1339005 | 0.76 | ALDH1A1 (0.42) | KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742947-B1 | 6-SUBSTITUTED PYRIDOINDOLONE DERIVATIVES PRODUCTION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2008-08-20 | — | — | EP | disclosed |