Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 10/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | PCK1 | P35558 | 4/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4767738 | 1.00 | ADORA2B (0.41) | ADORA2BADORA2AADORA1NCOA1NCOA3 | |
| SCHEMBL4763896 | 0.94 | ADORA2B (0.46) | ADORA2BADORA2AADORA1NCOA1NCOA3 | |
| SCHEMBL4763889 | 0.94 | ADORA2B (0.46) | ADORA2BADORA2AADORA1NCOA1NCOA3 | |
| SCHEMBL4762309 | 0.93 | ADORA2B (0.39) | ADORA2BADORA2AADORA1ADORA3MAPT | |
| SCHEMBL4762305 | 0.93 | ADORA2B (0.39) | ADORA2BADORA2AADORA1ADORA3MAPT | |
| SCHEMBL4770831 | 0.91 | ADORA2B (0.43) | ADORA2BADORA2AADORA1NCOA1NCOA3 | |
| SCHEMBL4770837 | 0.91 | ADORA2B (0.43) | ADORA2BADORA2AADORA1NCOA1NCOA3 | |
| SCHEMBL4763211 | 0.89 | ADORA2B (0.42) | ADORA2BADORA2AADORA1NCOA1NCOA3 | |
| SCHEMBL4771531 | 0.88 | ADORA2B (0.38) | ADORA2BADORA2AADORA1ADORA3MAPT | |
| SCHEMBL4771549 | 0.88 | ADORA2B (0.38) | ADORA2BADORA2AADORA1ADORA3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678181-B1 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2008-12-31 | — | — | EP | disclosed |