Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 9/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | GNRHR | P30968 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4771549 | 1.00 | ADORA2B (0.38) | ADORA2BADORA2AADORA1ADORA3TP53 | |
| SCHEMBL4765722 | 0.93 | TP53 (0.41) | ADORA2BADORA2AADORA1TP53TSHR | |
| SCHEMBL4765708 | 0.93 | TP53 (0.41) | ADORA2BADORA2AADORA1TP53TSHR | |
| SCHEMBL4762309 | 0.93 | ADORA2B (0.39) | ADORA2BADORA2AADORA1ADORA3GNRHR | |
| SCHEMBL4762305 | 0.93 | ADORA2B (0.39) | ADORA2BADORA2AADORA1ADORA3GNRHR | |
| SCHEMBL4764018 | 0.91 | ADORA2B (0.41) | ADORA2BADORA2AADORA1ADORA3GNRHR | |
| SCHEMBL4764008 | 0.91 | ADORA2B (0.41) | ADORA2BADORA2AADORA1ADORA3GNRHR | |
| SCHEMBL4767738 | 0.88 | ADORA2B (0.41) | ADORA2BADORA2AADORA1ADORA3MAPT | |
| SCHEMBL4767746 | 0.88 | ADORA2B (0.41) | ADORA2BADORA2AADORA1ADORA3MAPT | |
| SCHEMBL4771540 | 0.86 | ADORA2B (0.40) | ADORA2BADORA2AADORA1ADORA3GNRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678181-B1 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2008-12-31 | — | — | EP | disclosed |