Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 3/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 4/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | ACACA | Q13085 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4775802 | 0.86 | GCGR (0.49) | GCGRCDC7CDK5CDK5R1MAPK14 | |
| Hydrochloric Acid SCHEMBL4771889 | 0.83 | GCGR (0.50) | GCGRCDC7CDK5CDK5R1MAPK14 | |
| SCHEMBL4771352 | 0.81 | ATM (0.46) | GCGRSYKCDC7CDK5CDK5R1 | |
| SCHEMBL4767661 | 0.77 | GCGR (0.46) | GCGRCDC7CDK5CDK5R1MAPK14 | |
| SCHEMBL4768810 | 0.76 | GCGR (0.51) | GCGRCDC7CDK5CDK5R1MAPK14 | |
| SCHEMBL4767710 | 0.75 | GCGR (0.49) | GCGRCDC7CDK5CDK5R1MAPK14 | |
| SCHEMBL5346356 | 0.74 | GCGR (0.53) | GCGRCDC7CDK5CDK5R1MAPK14 | |
| SCHEMBL4774859 | 0.73 | GCGR (0.48) | GCGRCDC7CDK5CDK5R1MAPK14 | |
| Hydrochloric Acid SCHEMBL6466304 | 0.72 | CDC7 (0.53) | GCGRCDC7CDK5CDK5R1MAPK14 | |
| SCHEMBL4771823 | 0.71 | GCGR (0.46) | GCGRCDC7CDK5CDK5R1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660085-B1 | PYRIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-10-15 | — | — | EP | disclosed |
| US-20050043346-A1 | Pyridylpyrrole derivatives active as kinase inhibitors | PHARMACIA ITALIA S.P.A. (IT) | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043346-A1 | Pyridylpyrrole derivatives active as kinase inhibitors | MAP3K6, MAP3K5, MAP4K2 | GCGR 1852/4885SYK 585/4885CDC7 426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.