Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLB1 | P16278 | 1/20 | 0.37 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9820951 | 0.87 | CYP19A1 (0.40) | SIGMAR1 | |
| SCHEMBL7297794 | 0.87 | CYP19A1 (0.40) | SIGMAR1 | |
| SCHEMBL15229389 | 0.82 | GBA1 (0.47) | GBA1 | |
| SCHEMBL27644423 | 0.76 | KCNA3 (0.41) | — | |
| SCHEMBL6570849 | 0.73 | SLC18A2 (0.47) | — | |
| SCHEMBL3044569 | 0.71 | GBA1 (0.56) | GBA1 | |
| SCHEMBL6567840 | 0.71 | SLC18A2 (0.46) | — | |
| SCHEMBL5556878 | 0.70 | LTA4H (0.54) | GLB1GBA2 | |
| SCHEMBL3817645 | 0.70 | LTA4H (0.54) | GLB1GBA2 | |
| SCHEMBL293097 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007733-A1 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007113596-A1 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-10-11 | — | — | WO | disclosed |