Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.37 |
| ▸ | AXL | P30530 | 2/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MST1R | Q04912 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29821745 | 0.91 | MET (0.37) | METAXLHCRTR2EGFRIGF1R | |
| SCHEMBL20588392 | 0.86 | MET (0.37) | METAXLEGFRIGF1RKIT | |
| SCHEMBL29821807 | 0.85 | KIT (0.41) | METAXLKIT | |
| SCHEMBL20588989 | 0.85 | MET (0.34) | METAXLBRAFEGFRIGF1R | |
| SCHEMBL20587650 | 0.85 | ATM (0.38) | AXL | |
| SCHEMBL4767990 | 0.84 | ROCK2 (0.35) | METAXLBRAFRIPK2 | |
| SCHEMBL20588922 | 0.84 | KMT2A (0.44) | — | |
| SCHEMBL20588188 | 0.84 | MET (0.34) | METAXLBRAFEGFRIGF1R | |
| SCHEMBL20588225 | 0.84 | MET (0.34) | METAXLBRAFEGFRIGF1R | |
| SCHEMBL20659574 | 0.84 | MAP4K1 (0.37) | METAXLBRAFEGFRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751153-B1 | HETARYLOXY-SUBSTITUTED PHENYLAMINO PYRIMIDINES AS RHO KINASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2008-12-03 | — | — | EP | disclosed |
| EP-1751153-A1 | HETARYLOXY-SUBSTITUTED PHENYLAMINO PYRIMIDINES AS RHO KINASE INHIBITORS | Bayer HealthCare AG (DE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005097790-A1 | HETARYLOXY-SUBSTITUTED PHENYLAMINO PYRIMIDINES AS RHO KINASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2005-10-20 | — | — | WO | disclosed |