Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4135313 | 0.93 | KMT2A (0.39) | MEN1KMT2AHTTUSP2SMN1; SMN2 | |
| SCHEMBL4135320 | 0.93 | KMT2A (0.39) | MEN1KMT2AHTTUSP2SMN1; SMN2 | |
| SCHEMBL4140333 | 0.82 | HTT (0.40) | MEN1KMT2AHTTUSP2SMN1; SMN2 | |
| SCHEMBL4140336 | 0.82 | HTT (0.40) | MEN1KMT2AHTTUSP2SMN1; SMN2 | |
| SCHEMBL13889917 | 0.81 | LIPG (0.34) | MEN1KMT2AHTTMAPTLMNA | |
| SCHEMBL4139482 | 0.79 | LMNA (0.38) | HTTSMN1; SMN2LMNAALDH1A1LIPG | |
| SCHEMBL4139487 | 0.79 | LMNA (0.38) | HTTSMN1; SMN2LMNAALDH1A1LIPG | |
| SCHEMBL4127774 | 0.76 | KMT2A (0.45) | MEN1KMT2AHTTSMN1; SMN2NPSR1 | |
| SCHEMBL4136559 | 0.74 | LMNA (0.38) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL4136566 | 0.74 | LMNA (0.38) | MEN1KMT2AMAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940785-A2 | ACYCLIC 1,4-DIAMINES AND USES THEREOF | SmithKline Beecham Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007030761-A2 | ACYCLIC 1,4-DIAMINES AND USES THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |