Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.51 |
| ▸ | PLAT | P00750 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16132601 | 0.84 | KDM4E (0.54) | PLAUPLATKDM4EL3MBTL1MAPT | |
| SCHEMBL16132603 | 0.82 | MAPT (0.56) | PLAUPLATL3MBTL1MAPTMAPK1 | |
| SCHEMBL3692922 | 0.81 | KDM4E (0.45) | KDM4EL3MBTL1MAPTMAPK1TDP1 | |
| SCHEMBL3691358 | 0.80 | HTR1A (0.45) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL590679 | 0.79 | MAPT (0.55) | PLAUPLATKDM4EL3MBTL1MAPT | |
| SCHEMBL659166 | 0.77 | MAPT (0.50) | L3MBTL1MAPTMAPK1TDP1LMNA | |
| SCHEMBL16106577 | 0.76 | PLAU (0.44) | PLAUPLATKDM4EL3MBTL1MAPT | |
| SCHEMBL16106572 | 0.76 | PLAU (0.44) | PLAUPLATKDM4EL3MBTL1MAPT | |
| SCHEMBL2699726 | 0.76 | HTR1A (0.59) | PLAUKDM4EMAPTMAPK1TDP1 | |
| SCHEMBL31337072 | 0.76 | HTR1A (0.59) | PLAUKDM4EMAPTMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968587-A1 | SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZONAPHTHYRIDINES, AND IMIDAZOPYRIDINES, COMPOSITIONS, AND METHODS | Coley Pharmaceutical, Inc. (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007075468-A1 | SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZONAPHTHYRIDINES, AND IMIDAZOPYRIDINES, COMPOSITIONS, AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2007-07-05 | — | — | WO | disclosed |