Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 17/20 | 0.47 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.36 |
| ▸ | KIT | P10721 | 3/20 | 0.36 |
| ▸ | SRC | P12931 | 3/20 | 0.36 |
| ▸ | FLT3 | P36888 | 3/20 | 0.36 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772004 | 0.91 | KCNH2 (0.41) | CSF1RPDE4AKCNH2 | |
| SCHEMBL4773612 | 0.89 | CSF1R (0.40) | CSF1RPDE4AKCNH2 | |
| SCHEMBL4775827 | 0.86 | CSF1R (0.59) | CSF1RNTRK1KITSRCFLT3 | |
| SCHEMBL4777309 | 0.76 | CSF1R (0.57) | CSF1RNTRK1KITSRCFLT3 | |
| SCHEMBL4768934 | 0.74 | CSF1R (0.45) | CSF1RPDE4AKCNH2NTRK1KIT | |
| SCHEMBL4775340 | 0.72 | CSF1R (0.48) | CSF1RPDE4AKCNH2NTRK1KIT | |
| SCHEMBL4768393 | 0.72 | CSF1R (0.47) | CSF1RPDE4ANTRK1KITSRC | |
| SCHEMBL3294019 | 0.71 | CSF1R (0.75) | CSF1RNTRK1KITSRCFLT3 | |
| SCHEMBL11016385 | 0.70 | CSF1R (0.46) | CSF1RPDE4AKCNH2 | |
| SCHEMBL3289880 | 0.69 | CSF1R (0.56) | CSF1RNTRK1KITSRCFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945637-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-23 | — | — | EP | claimed |
| WO-2007033137-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | claimed |
| EP-1945637-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007033137-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | disclosed |