Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 18/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.39 |
| ▸ | KIT | P10721 | 3/20 | 0.39 |
| ▸ | SRC | P12931 | 3/20 | 0.39 |
| ▸ | FLT3 | P36888 | 3/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768393 | 0.97 | CSF1R (0.47) | CSF1RNTRK1KITSRCFLT3 | |
| SCHEMBL4773616 | 0.90 | CSF1R (0.43) | CSF1RPDE4AKCNH2 | |
| SCHEMBL4771887 | 0.88 | CSF1R (0.40) | CSF1RKITSRCFLT3PDE4A | |
| SCHEMBL4769014 | 0.87 | CSF1R (0.42) | CSF1RPDE4AKCNH2 | |
| SCHEMBL4773660 | 0.85 | CSF1R (0.56) | CSF1RNTRK1KITSRCFLT3 | |
| SCHEMBL4768934 | 0.80 | CSF1R (0.45) | CSF1RNTRK1KITSRCFLT3 | |
| SCHEMBL4775457 | 0.76 | CSF1R (0.57) | CSF1RNTRK1KITSRCFLT3 | |
| SCHEMBL4775792 | 0.73 | SLC6A2 (0.38) | CSF1RPDE4ACHEK1KCNH2 | |
| SCHEMBL4768307 | 0.72 | CSF1R (0.47) | CSF1RNTRK1KITSRCFLT3 | |
| SCHEMBL4763078 | 0.71 | CSF1R (0.58) | CSF1RNTRK1KITSRCFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945637-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007033137-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | disclosed |