Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4136296 | 0.76 | RAB9A (0.45) | RAB9ATRPV4PPARGPTGDRPTGDR2 | |
| SCHEMBL4131127 | 0.75 | RAB9A (0.39) | RAB9ATRPV4PPARGPTGDRPTGDR2 | |
| SCHEMBL4132376 | 0.74 | GAA (0.42) | RAB9APPARGHSD11B1CA12CA1 | |
| SCHEMBL4131282 | 0.74 | TRPV4 (0.44) | RAB9ATRPV4PPARGHSD11B1PTGDR | |
| SCHEMBL4152609 | 0.73 | TRPV4 (0.40) | RAB9ATRPV4CA12CA1CA2 | |
| SCHEMBL14605593 | 0.73 | RAB9A (0.42) | RAB9APPARGHSD11B1CA12CA1 | |
| SCHEMBL4777734 | 0.71 | TRPV4 (0.55) | TRPV4 | |
| SCHEMBL14606018 | 0.71 | RAB9A (0.42) | RAB9ATRPV4PPARGHSD11B1CA12 | |
| SCHEMBL4135553 | 0.71 | CCR1 (0.40) | RAB9APPARGHSD11B1PTGDRPTGDR2 | |
| SCHEMBL4136186 | 0.70 | TRPV4 (0.39) | RAB9ATRPV4PPARGHSD11B1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940785-A2 | ACYCLIC 1,4-DIAMINES AND USES THEREOF | SmithKline Beecham Corporation (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007030761-A2 | ACYCLIC 1,4-DIAMINES AND USES THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | claimed |