Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 1/20 | 0.45 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.45 |
| ▸ | CCR1 | P32246 | 10/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 4/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6634574 | 0.87 | GRN (0.52) | GRNSORT1CCR1PSMB5CTSK | |
| SCHEMBL4763062 | 0.86 | GRN (0.47) | GRNSORT1CCR1PSMB5CTSK | |
| SCHEMBL4761986 | 0.85 | GRN (0.47) | GRNSORT1CCR1PSMB5CTSK | |
| SCHEMBL6588637 | 0.85 | GRN (0.47) | GRNSORT1CCR1PSMB5CTSK | |
| SCHEMBL4770999 | 0.85 | GRN (0.47) | GRNSORT1CCR1PSMB5CTSK | |
| SCHEMBL4765859 | 0.85 | GRN (0.47) | GRNSORT1CCR1PSMB5CTSK | |
| SCHEMBL6588642 | 0.85 | GRN (0.47) | GRNSORT1CCR1PSMB5CTSK | |
| SCHEMBL4767092 | 0.85 | CTSK (0.44) | CTSKCTSBCTSS | |
| SCHEMBL4765376 | 0.84 | CTSK (0.31) | CTSKCTSLCTSBCTSS | |
| SCHEMBL6590376 | 0.84 | GRN (0.45) | GRNSORT1CCR1PSMB5CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320370-A4 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1320370-A1 | METHOD OF TREATMENT | SmithKline Beecham Corporation (US) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002017924-A1 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORPORATION (GB) | 2002-03-07 | — | — | WO | disclosed |