Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | C1S | P09871 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768785 | 1.00 | PTGS2 (0.55) | PTGS2PARP1ALDH1A1TP53MAPT | |
| SCHEMBL5206467 | 0.81 | PTGS2 (0.70) | PTGS2PARP1ALDH1A1MAPTHPGD | |
| SCHEMBL30522332 | 0.81 | PTGS2 (0.55) | PTGS2PARP1ALDH1A1TP53MAPT | |
| SCHEMBL8795911 | 0.81 | PTGS2 (0.70) | PTGS2PARP1ALDH1A1MAPTHPGD | |
| SCHEMBL2582001 | 0.80 | PTGS2 (0.53) | PTGS2PARP1ALDH1A1TP53MAPT | |
| SCHEMBL2582000 | 0.80 | PTGS2 (0.53) | PTGS2PARP1ALDH1A1TP53MAPT | |
| SCHEMBL10367778 | 0.78 | CES2 (0.57) | PARP1HPGDAKR1C3AKR1C2SMN1; SMN2 | |
| SCHEMBL3069399 | 0.78 | AKR1C1 (0.61) | PTGS2PARP1ALDH1A1MAPTHPGD | |
| SCHEMBL6474719 | 0.78 | AKR1C1 (0.61) | PTGS2PARP1ALDH1A1MAPTHPGD | |
| SCHEMBL2383745 | 0.77 | CYP19A1 (0.48) | PTGS2PARP1ALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742947-B1 | 6-SUBSTITUTED PYRIDOINDOLONE DERIVATIVES PRODUCTION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2008-08-20 | — | — | EP | disclosed |
| EP-1556382-B1 | 3-PHENYL SUBSTITUTED PYRIDOINDOLONE, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2008-05-28 | — | — | EP | disclosed |
| EP-1742947-A1 | 6-SUBSTITUTED PYRIDOINDOLONE DERIVATIVES PRODUCTION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005108398-A1 | 6-SUBSTITUTED PYRIDOINDOLONE DERIVATIVES PRODUCTION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2005-11-17 | — | — | WO | disclosed |
| EP-1556382-A1 | 3-PHENYL SUBSTITUTED PYRIDOINDOLONE, PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004041817-A1 | 3-PHENYL SUBSTITUTED PYRIDOINDOLONE, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2004-05-21 | — | — | WO | disclosed |