Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 18/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4769016 | 1.00 | C5AR1 (0.37) | C5AR1HSD11B1ADORA2AADORA2BADORA1 | |
| SCHEMBL4763924 | 0.91 | NPSR1 (0.33) | ADORA2AADORA2BADORA1 | |
| SCHEMBL4763921 | 0.91 | NPSR1 (0.33) | ADORA2AADORA2BADORA1 | |
| SCHEMBL4763420 | 0.90 | ADORA2A (0.39) | ADORA2AADORA2BADORA1 | |
| SCHEMBL4763418 | 0.90 | ADORA2A (0.39) | ADORA2AADORA2BADORA1 | |
| SCHEMBL4762674 | 0.89 | ADORA2A (0.36) | C5AR1HSD11B1ADORA2AADORA2BADORA1 | |
| SCHEMBL4762676 | 0.89 | ADORA2A (0.36) | C5AR1HSD11B1ADORA2AADORA2BADORA1 | |
| SCHEMBL4895305 | 0.86 | ADORA2A (0.40) | C5AR1HSD11B1ADORA2AADORA2BADORA1 | |
| SCHEMBL4766007 | 0.85 | C5AR1 (0.41) | C5AR1HSD11B1ADORA2AADORA2BADORA1 | |
| SCHEMBL4763634 | 0.84 | ADORA2A (0.35) | ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678181-B1 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2008-12-31 | — | — | EP | disclosed |