Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.44 |
| ▸ | CCNC | P24863 | 2/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5120623 | 0.81 | HSD17B10 (0.56) | ELANETSHRPOLBHSD17B10SLC22A12 | |
| SCHEMBL30854946 | 0.81 | EGFR (0.41) | ELANEHDAC8CHEK1AURKADAPK3 | |
| SCHEMBL4140238 | 0.79 | CHEK1 (0.57) | ELANECCNCCDK8HDAC8CHEK1 | |
| SCHEMBL30457321 | 0.77 | CHEK1 (0.67) | ELANETSHRPOLBHSD17B10MAPT | |
| Hydrochloric Acid SCHEMBL5049276 | 0.74 | TSHR (0.38) | TSHRPOLBHSD17B10MAPTHPGD | |
| SCHEMBL9209985 | 0.74 | HSD17B10 (0.43) | ELANETSHRPOLBHSD17B10MAPT | |
| SCHEMBL14193258 | 0.72 | ASAH1 (0.53) | ELANETSHRPOLBHSD17B10SLC22A12 | |
| SCHEMBL4909163 | 0.70 | SLC22A12 (0.49) | ELANECCNCCDK8MAPTMAPK14 | |
| SCHEMBL30786241 | 0.70 | ASAH1 (0.57) | ELANETSHRPOLBHSD17B10MAPT | |
| SCHEMBL20028166 | 0.69 | NPC1 (0.40) | ELANECCNCCDK8HSD17B10NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968976-A1 | SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007068619-A1 | SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-06-21 | — | — | WO | disclosed |