Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 10/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.34 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4766139 | 0.95 | ADORA2B (0.49) | ADORA2BADORA1ADORA2ANCOA1NCOA3 | |
| SCHEMBL4763384 | 0.95 | ADORA2B (0.44) | ADORA2BADORA1ADORA2ANCOA1NCOA3 | |
| SCHEMBL4770747 | 0.95 | ADORA2B (0.48) | ADORA2BADORA1ADORA2ANCOA1NCOA3 | |
| SCHEMBL4770754 | 0.95 | ADORA2B (0.48) | ADORA2BADORA1ADORA2ANCOA1NCOA3 | |
| SCHEMBL4766145 | 0.92 | ADORA2B (0.41) | ADORA2BADORA1ADORA2ANCOA1NCOA3 | |
| SCHEMBL4763211 | 0.91 | ADORA2B (0.42) | ADORA2BADORA1ADORA2ANCOA1NCOA3 | |
| SCHEMBL4770837 | 0.90 | ADORA2B (0.43) | ADORA2BADORA1ADORA2ANCOA1NCOA3 | |
| SCHEMBL4770831 | 0.90 | ADORA2B (0.43) | ADORA2BADORA1ADORA2ANCOA1NCOA3 | |
| SCHEMBL4769323 | 0.89 | ADORA2B (0.42) | ADORA2BADORA1ADORA2ANCOA1NCOA3 | |
| SCHEMBL4769690 | 0.87 | ADORA2B (0.52) | ADORA2BADORA1ADORA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678181-B1 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2008-12-31 | — | — | EP | disclosed |