M-Xylene

M-Xylene

SCHEMBL4769348

C.Cc1cccc(C)c1.Cc1cccc(C)c1.N=C=O.N=C=O

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 5/20 0.63
ALDH1A1 P00352 2/20 0.44
MAPK1 P28482 1/20 0.44
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
PARP1 P09874 1/20 0.41
TSHR P16473 1/20 0.41
TP53 P04637 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
LMNA P02545 1/20 0.39
HSP90AA1 P07900 1/20 0.39
MGLL Q99685 1/20 0.39
HSD17B10 Q99714 1/20 0.39
NPC1 O15118 1/20 0.38
CASP3 P42574 1/20 0.38
SENP8 Q96LD8 1/20 0.38
SENP7 Q9BQF6 1/20 0.38
SENP6 Q9GZR1 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
M-Xylene SCHEMBL31383510 0.97 ACHE (0.67) ACHEALDH1A1MAPK1HDAC8HDAC6
M-Xylene SCHEMBL27020 0.97 ACHE (0.67) ACHEALDH1A1MAPK1HDAC8HDAC6
M-Xylene SCHEMBL28204206 0.97 ACHE (0.67) ACHEALDH1A1MAPK1HDAC8HDAC6
M-Xylene SCHEMBL163239 0.97 ACHE (0.67) ACHEALDH1A1MAPK1HDAC8HDAC6
M-Xylene SCHEMBL28613777 0.90 ACHE (0.57) ACHEALDH1A1MAPK1PARP1TSHR
M-Xylene SCHEMBL28493229 0.88 ACHE (0.55) ACHEALDH1A1MAPK1HDAC8HDAC6
Methane SCHEMBL29103903 0.88 ACHE (0.48) ACHEALDH1A1TSHRNPC1MAPT
Naphthalene SCHEMBL9068412 0.88 ACHE (0.55) ACHEALDH1A1MAPK1PARP1TSHR
Naphthalene SCHEMBL27950601 0.88 ACHE (0.55) ACHEALDH1A1MAPK1PARP1TSHR
SCHEMBL476272 0.86 ACHE (0.52) ACHEALDH1A1MAPK1PARP1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1569978-B1 POLYURETHANEUREA AND SPANDEX COMPRISING SAME INVISTA TECH SARL (CH) 2008-10-22 EP disclosed
EP-1569978-A1 POLYURETHANEUREA AND SPANDEX COMPRISING SAME INVISTA Technologies S.à.r.l. (US) 2005-09-07 EP disclosed
WO-2004041895-A1 POLYURETHANEUREA AND SPANDEX COMPRISING SAME INVISTA TECHNOLOGIES S.À.R.L. (US) 2004-05-21 WO disclosed
US-6720403-B1 GOOD WHITENESS RETENTION, HIGH HEAT-SET EFFICIENCY; POLYMERIC GLYCOL, ALKYL SUBSTITUTED METHYLENEBIS(4-ISOCYANATOBENZENE), A DOUBLY-HINDERED DIAMINE E.I. DUPONT DE NEMOURS AND CO. 2004-04-13 US disclosed