SCHEMBL476943

SCHEMBL476943

CCOc1ccc(CCN2C(=O)c3ccccc3C2=O)cc1OCC

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.76
CYP3A4 P08684 1/20 0.67
CYP2C9 P11712 1/20 0.67
CYP2C19 P33261 1/20 0.67
L3MBTL1 Q9Y468 3/20 0.57
ALDH1A1 P00352 2/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
LMNA P02545 2/20 0.52
ADRA1D P25100 1/20 0.51
ADRA1A P35348 1/20 0.51
ADRA1B P35368 1/20 0.51
MGAM O43451 1/20 0.49
GAA P10253 1/20 0.49
SI P14410 1/20 0.49
MGAM2 Q2M2H8 1/20 0.49
CASP3 P42574 1/20 0.49
TP53 P04637 1/20 0.48
MAPT P10636 1/20 0.48
HPGD P15428 1/20 0.48
TSHR P16473 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8777033 0.92 CYP3A4 (0.71) KMT2ACYP3A4CYP2C9CYP2C19L3MBTL1
SCHEMBL8777031 0.91 CYP3A4 (0.69) KMT2ACYP3A4CYP2C9CYP2C19L3MBTL1
SCHEMBL13081239 0.87 CYP3A4 (0.66) KMT2ACYP3A4CYP2C9CYP2C19L3MBTL1
SCHEMBL8777049 0.83 LMNA (0.72) ALDH1A1SMN1; SMN2LMNAMAPTHPGD
SCHEMBL8777025 0.82 KMT2A (0.55) KMT2ACYP3A4CYP2C9CYP2C19L3MBTL1
SCHEMBL7886525 0.82 RAB9A (0.57) KMT2ACYP3A4CYP2C9CYP2C19L3MBTL1
SCHEMBL8777023 0.79 TNF (0.56) KMT2ACYP3A4CYP2C9CYP2C19L3MBTL1
SCHEMBL24715918 0.78 KMT2A (0.50) KMT2ACYP3A4CYP2C9CYP2C19L3MBTL1
SCHEMBL17721716 0.78 KMT2A (0.50) KMT2ACYP3A4CYP2C9CYP2C19L3MBTL1
SCHEMBL9633218 0.77 RAB9A (0.59) KMT2ACYP3A4CYP2C9CYP2C19L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019164891-A9 BCMA-BINDING ANTIBODIES AND USES THEREOF CELGENE CORPORATION (US) 2020-09-17 WO disclosed
EP-3313818-A1 METHODS FOR THE TREATMENT OF KAPOSI'S SARCOMA OR KSHV-INDUCED LYMPHOMA USING IMMUNOMODULATORY COMPOUNDS, AND USES OF BIOMARKERS Celgene Corporation (US) 2018-05-02 EP disclosed
WO-2016210262-A1 METHODS FOR THE TREATMENT OF KAPOSI'S SARCOMA OR KSHV-INDUCED LYMPHOMA USING IMMUNOMODULATORY COMPOUNDS, AND USES OF BIOMARKERS CELGENE CORPORATION (US) 2016-12-29 WO disclosed
EP-3077548-A2 METHODS FOR DETERMINING DRUG EFFICACY FOR THE TREATMENT OF DIFFUSE LARGE B-CELL LYMPHOMA, MULTIPLE MYELOMA, AND MYELOID CANCERS Celgene Corporation (US) 2016-10-12 EP disclosed
EP-3077547-A2 METHODS FOR TREATING HEMATOLOGICAL CANCERS AND THE USE OF BIOMARKERS AS A PREDICTOR OF CLINICAL SENSITIVITY TO IMMUNODULATORY THERAPIES Celgene Corporation (US) 2016-10-12 EP disclosed
WO-2015085160-A2 METHODS FOR TREATING HEMATOLOGICAL CANCERS AND THE USE OF BIOMARKERS AS A PREDICTOR OF CLINICAL SENSITIVITY TO IMMUNODULATORY THERAPIES CELGENE CORPORATION (US) 2015-06-11 WO disclosed
WO-2015085172-A2 METHODS FOR DETERMINING DRUG EFFICACY FOR THE TREATMENT OF DIFFUSE LARGE B-CELL LYMPHOMA, MULTIPLE MYELOMA, AND MYELOID CANCERS CELGENE CORPORATION (US) 2015-06-11 WO disclosed
EP-2867671-A2 METHODS FOR DETERMINING DRUG EFFICACY USING CEREBLON-ASSOCIATED PROTEINS Celgene Corporation (US) 2015-05-06 EP disclosed
EP-2699909-A1 BIOMARKERS FOR THE TREATMENT OF MULTIPLE MYELOMA Celgene Corporation (US) 2014-02-26 EP disclosed
WO-2014028445-A2 CEREBLON ISOFORMS AND THEIR USE AS BIOMARKERS FOR THERAPEUTIC TREATMENT CELGENE CORPORATION (US) 2014-02-20 WO disclosed
WO-2014004990-A2 METHODS FOR DETERMINING DRUG EFFICACY USING CEREBLON-ASSOCIATED PROTEINS CELGENE CORPORATION (US) 2014-01-03 WO disclosed
EP-2521543-A1 A COMBINATION OF AN IMMUNOMODULATORY COMPOUND AND AN ARTEMISININ OR A DERIVATIVE THEREOF FOR TREATING CANCER Celgene Corporation (US) 2012-11-14 EP disclosed
WO-2012145309-A1 BIOMARKERS FOR THE TREATMENT OF MULTIPLE MYELOMA CELGENE CORPORATION (US) 2012-10-26 WO disclosed
EP-2411506-A1 TUMOR SUPPRESSION USING HUMAN PLACENTA-DERIVED INTERMEDIATE NATURAL KILLER CELLS AND IMMUNOMODULATORY COMPOUNDS Anthrogenesis Corporation (US) 2012-02-01 EP disclosed
WO-2011084968-A1 A COMBINATION OF AN IMMUNOMODULATORY COMPOUND AND AN ARTEMISININ OR A DERIVATIVE THEREOF FOR TREATING CANCER CELGENE CORPORATION (US) 2011-07-14 WO disclosed
EP-2235535-A2 BIOMARKERS FOR PREDICTING THE SENSITIVITY OF CELLS TO IMMUNOMODULATORY COMPOUNDS DURING TREATMENT OF NON-HODGKIN'S LYMPHOMA CELGENE CORPORATION (US) 2010-10-06 EP disclosed
WO-2010111631-A1 TUMOR SUPPRESSION USING HUMAN PLACENTA-DERIVED INTERMEDIATE NATURAL KILLER CELLS AND IMMUNOMODULATORY COMPOUNDS ANTHROGENESIS CORPORATION (US) 2010-09-30 WO disclosed
WO-2009105256-A2 METHOD OF TREATING CANCER BY ADMINISTERING AN IMMUNOMODULATORY COMPOUND IN COMBINATION WITH A CD40 ANTIBODY OR CD40 LIGAND CELGENE CORPORATION (US) 2009-08-27 WO disclosed
WO-2009085262-A1 METHOD OF TREATING CANCER WITH IMMUNOMODULATORY COMPOUNDS AND IGG CELGENE CORPORATION (US) 2009-07-09 WO disclosed
WO-2009075797-A2 BIOMARKERS FOR PREDICTING THE SENSITIVITY OF CELLS TO IMMUNOMODULATORY COMPOUNDS DURING TREATMENT OF NON-HODGKIN'S LYMPHOMA CELGENE CORPORATION (US) 2009-06-18 WO disclosed