Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 7/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4174770 | 0.94 | RAF1 (0.41) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4770425 | 0.78 | RAF1 (0.31) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13906519 | 0.77 | L3MBTL1 (0.38) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4176375 | 0.77 | KDM4E (0.42) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4769679 | 0.76 | KDM4E (0.36) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL14155908 | 0.73 | HDAC2 (0.44) | — | |
| SCHEMBL4169623 | 0.72 | RAF1 (0.44) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4769749 | 0.71 | RAF1 (0.43) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13906521 | 0.70 | ALDH1A1 (0.36) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4166230 | 0.70 | ALDH1A1 (0.36) | RAF1MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987042-A2 | NOVEL AMINO ALCOHOL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | sanofi-aventis (FR) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007093365-A2 | NOVEL AMINO ALCOHOL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | SANOFI-AVENTIS (DE) | 2007-08-23 | — | — | WO | disclosed |