Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938100 | 0.78 | MAPT (0.50) | KMT2AMAPTSMN1; SMN2CYP2C19HIF1A | |
| SCHEMBL21644502 | 0.77 | KMT2A (0.48) | KMT2AMAPTSMN1; SMN2POLBCYP2C19 | |
| SCHEMBL4561507 | 0.75 | CYP2D6 (0.50) | KMT2AMAPTCYP2C19HIF1AHTT | |
| SCHEMBL28780291 | 0.74 | SMN1; SMN2 (0.40) | KMT2ASMN1; SMN2POLBCYP2C19HIF1A | |
| SCHEMBL27845934 | 0.72 | KCNN4 (0.41) | KMT2AMAPTSMN1; SMN2POLBCYP2C19 | |
| SCHEMBL28288133 | 0.71 | SMN1; SMN2 (0.38) | KMT2ASMN1; SMN2POLBCYP2C19HTT | |
| SCHEMBL8573483 | 0.71 | ALDH1A1 (0.39) | KMT2AMAPTSMN1; SMN2POLBCYP2C19 | |
| SCHEMBL28859615 | 0.70 | CYP2C19 (0.47) | KMT2AMAPTSMN1; SMN2POLBCYP2C19 | |
| SCHEMBL3685988 | 0.70 | TAAR1 (0.45) | KMT2AMAPTSMN1; SMN2CYP2C19HIF1A | |
| SCHEMBL1357103 | 0.70 | ALDH1A1 (0.45) | KMT2AMAPTSMN1; SMN2POLBCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981837-A2 | METHODS AND COMPOSITIONS FOR MODULATING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ACTIVITY | Praecis Pharmaceuticals Incorporated (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007092190-A2 | METHODS AND COMPOSITIONS FOR MODULATING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ACTIVITY | PRAECIS PHARMACEUTICALS, INC. (US) | 2007-08-16 | — | — | WO | disclosed |