Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL455527 | 1.00 | HTR6 (0.67) | HTR6KMT2AHPGDSMN1; SMN2HRH3 | |
| SCHEMBL28008874 | 1.00 | HTR6 (0.67) | HTR6KMT2AHPGDSMN1; SMN2HRH3 | |
| Fluoride SCHEMBL28240221 | 0.98 | HTR6 (0.64) | HTR6KMT2AHPGDSMN1; SMN2HRH3 | |
| Hydrochloric Acid SCHEMBL11395977 | 0.98 | HTR6 (0.64) | HTR6KMT2AHPGDSMN1; SMN2HRH3 | |
| Ammonia Solution, Strong SCHEMBL11389061 | 0.98 | HTR6 (0.64) | HTR6KMT2AHPGDSMN1; SMN2HRH3 | |
| SCHEMBL29835975 | 0.96 | HTR6 (0.62) | HTR6KMT2AHPGDSMN1; SMN2HRH3 | |
| Hydrochloric Acid SCHEMBL11443374 | 0.96 | HTR6 (0.62) | HTR6KMT2AHPGDSMN1; SMN2HRH3 | |
| SCHEMBL3689659 | 0.96 | HTR6 (0.59) | HTR6KMT2AHRH3ALDH1A1L3MBTL3 | |
| SCHEMBL25639610 | 0.96 | HTR6 (0.59) | HTR6KMT2AHRH3ALDH1A1L3MBTL3 | |
| SCHEMBL8884589 | 0.94 | HTR6 (0.60) | HTR6KMT2AHPGDSMN1; SMN2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331546-B1 | 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-IB]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF | SANOFI SA (FR) | 2012-02-01 | — | — | EP | claimed |
| US-20110312934-A1 | 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2011-12-22 | — | — | US | claimed |
| US-4921855-A | New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-05-01 | — | — | US | claimed |
| US-20110312934-A1 | 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2011-12-22 | — | — | US | disclosed |
| EP-1032613-B1 | REACTIVE DISAZO DYES | DYSTAR TEXTILFARBEN GMBH & CO (DE) | 2003-02-19 | — | — | EP | disclosed |
| US-6191264-B1 | DYEBASE A CENTRAL 1-HYDROXY-8-AMINONAPHTHALENESULFONIC ACID WITH TERMINAL BENZENE NUCLEI EACH WITH A REACTIVE TRIAZINYLAMINO GROUP, AT LEAST ONE OF WHICH HAS ON THE TRIAZINYL NUCLEUS A CARBAMOYL ALKYLAMINO GROUP | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312934-A1 | 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF | NR3C1, CNKSR1, NR3C2 | HTR6 382/4885KMT2A 3677/4885HPGD 2248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.