Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 4/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.45 |
| ▸ | RNASEL | Q05823 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CLK3 | P49761 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4765545 | 0.86 | DYRK3 (0.57) | DYRK3PTPN11MAPTCSNK1ECLK1 | |
| SCHEMBL2786591 | 0.85 | DYRK3 (0.73) | DYRK3RNASELNPSR1MAPTCSNK1E | |
| SCHEMBL13196770 | 0.85 | DYRK3 (0.73) | DYRK3RNASELNPSR1MAPTCSNK1E | |
| SCHEMBL2786592 | 0.85 | DYRK3 (0.73) | DYRK3RNASELNPSR1MAPTCSNK1E | |
| SCHEMBL4772766 | 0.83 | DYRK3 (0.69) | DYRK3PTPN11NPSR1CSNK1ECLK1 | |
| SCHEMBL4775509 | 0.82 | DYRK3 (0.55) | DYRK3PTPN11S1PR4CSNK1ECLK1 | |
| SCHEMBL4772146 | 0.82 | DYRK3 (0.54) | DYRK3PTPN11S1PR4RNASELCSNK1E | |
| SCHEMBL4774341 | 0.82 | MAPT (0.64) | DYRK3PTPN11RNASELNPSR1MAPT | |
| SCHEMBL4770650 | 0.80 | DYRK3 (0.48) | DYRK3PTPN11RNASELCSNK1ECLK1 | |
| SCHEMBL4775749 | 0.80 | MEN1 (0.48) | DYRK3PTPN11S1PR4NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567112-B1 | THIAZOLIDIN-4-ONES FOR INHIBITING hYAK3 PROTEINS | SMITHKLINE BEECHAM CORP (US) | 2008-10-15 | — | — | EP | claimed |