Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.48 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.45 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | GRN | P28799 | 1/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13543685 | 0.88 | GPBAR1 (0.56) | GPBAR1HTTALDH1A1TP53ALOX12 | |
| SCHEMBL16697113 | 0.86 | GPBAR1 (0.48) | GPBAR1HTTALDH1A1TP53ALOX12 | |
| SCHEMBL22897264 | 0.78 | HTT (0.60) | GPBAR1HTTALDH1A1TP53ALOX12 | |
| SCHEMBL28824095 | 0.77 | HTT (0.51) | GPBAR1HTTALDH1A1TP53ALOX12 | |
| SCHEMBL16004047 | 0.77 | GPBAR1 (1.00) | GPBAR1HTTALDH1A1NPC1RAB9A | |
| SCHEMBL8621188 | 0.75 | ALDH1A1 (0.49) | GPBAR1HTTALDH1A1TP53ALOX12 | |
| SCHEMBL27830568 | 0.74 | POLB (0.48) | HTTALDH1A1TP53ALOX12SMN1; SMN2 | |
| SCHEMBL4771914 | 0.74 | HTT (0.64) | GPBAR1HTTALDH1A1TP53ALOX12 | |
| SCHEMBL20028111 | 0.71 | TP53 (0.66) | HTTALDH1A1TP53ALOX12SLC5A1 | |
| SCHEMBL16697029 | 0.70 | SLC5A1 (0.57) | GPBAR1HTTALDH1A1TP53ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | disclosed |