Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4770760 | 0.94 | HRH3 (0.50) | HRH3HRH1ABCB1ABCG2NPC1 | |
| SCHEMBL5823896 | 0.85 | HRH3 (0.54) | HRH3HRH1NPC1TP53RAB9A | |
| SCHEMBL4775002 | 0.85 | RAB9A (0.53) | HRH3HRH1ABCB1ABCG2NPC1 | |
| SCHEMBL4772566 | 0.84 | RAB9A (0.57) | HRH3HRH1NPC1TP53RAB9A | |
| SCHEMBL4794145 | 0.84 | MAPT (0.53) | HRH3ABCB1ABCG2NPC1RAB9A | |
| SCHEMBL4765521 | 0.83 | HRH3 (0.57) | HRH3HRH1NPC1TP53RAB9A | |
| SCHEMBL4774177 | 0.83 | HRH3 (0.69) | HRH3HRH1NPC1TP53RAB9A | |
| SCHEMBL4770900 | 0.83 | HRH3 (0.56) | HRH3HRH1NPC1TP53RAB9A | |
| SCHEMBL4771503 | 0.83 | HRH3 (0.56) | HRH3HRH1NPC1TP53RAB9A | |
| SCHEMBL4767326 | 0.83 | RAB9A (0.71) | HRH3HRH1NPC1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |