Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.51 |
| ▸ | RELA | Q04206 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4765701 | 0.94 | MAPT (0.48) | MAPTRAB9ANPC1POLBMAPK1 | |
| SCHEMBL4775002 | 0.87 | RAB9A (0.53) | MAPTRAB9ANPC1SMN1; SMN2NFKB1 | |
| SCHEMBL4770901 | 0.84 | HRH3 (0.56) | MAPTRAB9ANPC1SMN1; SMN2NFKB1 | |
| SCHEMBL5823896 | 0.83 | HRH3 (0.54) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4794584 | 0.83 | MEN1 (0.48) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL4774628 | 0.82 | TMPRSS2 (0.61) | MAPTRAB9ANPC1POLBSMN1; SMN2 | |
| SCHEMBL4793943 | 0.82 | ABCB1 (0.55) | MAPTRAB9ANPC1SMN1; SMN2MEN1 | |
| Trifluoroacetic Acid SCHEMBL4765215 | 0.81 | SMN1; SMN2 (0.47) | MAPTRAB9ANPC1SMN1; SMN2NFKB1 | |
| SCHEMBL4770359 | 0.80 | ALDH1A1 (0.51) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4767427 | 0.79 | HRH3 (0.50) | MAPTRAB9ANPC1SMN1; SMN2NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |