Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4793581 | 0.94 | RECQL (0.41) | RECQLHPGDKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL4775217 | 0.85 | RECQL (0.56) | RECQLHPGDKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL4777398 | 0.85 | KMT2A (0.45) | KMT2ANPC1ALDH1A1LMNAMEN1 | |
| SCHEMBL4775167 | 0.84 | KDM4E (0.39) | SMN1; SMN2ALDH1A1LMNAKDM4EGAA | |
| SCHEMBL4771345 | 0.78 | RECQL (0.60) | RECQLHPGDKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL4773589 | 0.75 | RECQL (0.52) | RECQLHPGDKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL4767621 | 0.69 | RECQL (0.49) | RECQLKMT2ANPC1POLBALDH1A1 | |
| SCHEMBL4774938 | 0.68 | RECQL (0.49) | RECQLHPGDKMT2ASMN1; SMN2POLB | |
| SCHEMBL5360990 | 0.68 | GRIN2B (0.47) | HPGDKMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL14425383 | 0.68 | GRIN2B (0.47) | HPGDKMT2ASMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942888-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-07-16 | — | — | EP | claimed |
| WO-2007056078-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | claimed |