Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4775167 | 0.90 | KDM4E (0.39) | KDM4EALDH1A1LMNATPSAB1GAA | |
| SCHEMBL4770946 | 0.85 | RECQL (0.39) | KMT2AKDM4EALDH1A1NPC1LMNA | |
| SCHEMBL4767621 | 0.85 | RECQL (0.49) | KMT2AKDM4EALDH1A1NPC1LMNA | |
| SCHEMBL4793581 | 0.78 | RECQL (0.41) | KMT2AALDH1A1NPC1LMNAMEN1 | |
| SCHEMBL5571955 | 0.74 | ACKR3 (0.49) | KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL4774938 | 0.74 | RECQL (0.49) | KMT2AKDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL4775217 | 0.69 | RECQL (0.56) | KMT2AALDH1A1NPC1LMNAMEN1 | |
| SCHEMBL5571930 | 0.67 | ALDH1A1 (0.56) | KMT2AKDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL5567967 | 0.66 | KDM4E (0.58) | KDM4EALDH1A1LMNAGAA | |
| SCHEMBL4777532 | 0.65 | SLC6A4 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942888-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007056078-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |