Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24950120 | 0.74 | TAAR1 (0.48) | TAAR1NFE2L2HTR2AHTR2CHTR2B | |
| SCHEMBL12215973 | 0.71 | TSHR (0.36) | TAAR1HTR2CHTR2BKDM1ARCOR1 | |
| SCHEMBL19559642 | 0.70 | HTR2A (0.44) | TAAR1NFE2L2HTR2AHTR2CHTR2B | |
| SCHEMBL29878889 | 0.68 | HTR2C (0.47) | TAAR1HTR2AHTR2CHTR2BNPC1 | |
| SCHEMBL1515236 | 0.68 | HTR2C (0.47) | TAAR1HTR2AHTR2CHTR2BNPC1 | |
| SCHEMBL25422037 | 0.68 | HTR2A (0.43) | TAAR1NFE2L2HTR2AHTR2CHTR2B | |
| SCHEMBL19119387 | 0.67 | HTR2A (0.42) | TAAR1HTR2AHTR2CHTR2BNOS3 | |
| SCHEMBL4074066 | 0.67 | HTR2A (0.46) | TAAR1NFE2L2HTR2AHTR2CHTR2B | |
| SCHEMBL13329 | 0.66 | — | — | |
| SCHEMBL5119013 | 0.66 | P2RX7 (0.41) | TAAR1NFE2L2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111732545-B | 2, 3-dihydrospiro [ imidazole-4, 1 ′ -indene]Compounds and preparation method thereof | 华侨大学 | 2023-03-10 | — | — | CN | disclosed |
| CN-111732545-A | 2, 3-dihydrospiro [ imidazole-4, 1′-indene]Compounds and preparation method thereof | UNIV HUAQIAO | 2020-10-02 | — | — | CN | disclosed |
| EP-1971596-A2 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS MINERALOCORTICOID RECEPTOR LIGANDS | Takeda Pharmaceutical Company Limited (JP) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007077961-A2 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS MINERALOCORTICOID RECEPTOR LIGANDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-07-12 | — | — | WO | disclosed |