Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.64 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4767946 | 0.93 | HRH3 (0.56) | HRH3TMPRSS2KMT2AMCHR1RAB9A | |
| SCHEMBL4768500 | 0.92 | HRH3 (0.57) | HRH3TMPRSS2RAB9ANPC1 | |
| SCHEMBL4773028 | 0.89 | RAB9A (0.60) | HRH3KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL4765905 | 0.88 | NPC1 (0.69) | HRH3TMPRSS2KMT2AMCHR1RAB9A | |
| SCHEMBL4774646 | 0.87 | HRH3 (0.67) | HRH3RAB9ANPC1SMN1; SMN2NFKB1 | |
| Trifluoroacetic Acid SCHEMBL4767622 | 0.86 | HRH3 (0.51) | HRH3TMPRSS2RAB9ANPC1TRPV1 | |
| SCHEMBL4768058 | 0.85 | NPC1 (0.69) | HRH3KMT2AMCHR1RAB9ANPC1 | |
| SCHEMBL4765225 | 0.85 | HRH3 (0.55) | HRH3TMPRSS2RAB9ANPC1ALDH1A1 | |
| SCHEMBL4770574 | 0.84 | HRH3 (0.57) | HRH3KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL4768623 | 0.83 | RAB9A (0.58) | HRH3TMPRSS2MCHR1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |