Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.60 |
| ▸ | NPC1 | O15118 | 8/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | QSOX1 | O00391 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.52 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4770822 | 0.94 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2ALDH1A1PKM | |
| SCHEMBL4770633 | 0.89 | HRH3 (0.64) | RAB9ANPC1SMN1; SMN2PKMMEN1 | |
| SCHEMBL4768500 | 0.89 | HRH3 (0.57) | RAB9ANPC1KDM2BHRH3 | |
| SCHEMBL4771074 | 0.89 | HRH3 (0.64) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4767344 | 0.86 | TDP1 (0.58) | RAB9ANPC1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4772670 | 0.84 | NPC1 (0.71) | RAB9ANPC1SMN1; SMN2ALDH1A1PKM | |
| SCHEMBL4772154 | 0.84 | NPC1 (0.52) | RAB9ANPC1SMN1; SMN2ALDH1A1LMNA | |
| Trifluoroacetic Acid SCHEMBL4770267 | 0.84 | HRH3 (0.57) | RAB9ANPC1SMN1; SMN2PKMMEN1 | |
| SCHEMBL4770046 | 0.84 | RORC (0.60) | RAB9ANPC1SMN1; SMN2KMT2ANFKB1 | |
| Trifluoroacetic Acid SCHEMBL4767622 | 0.83 | HRH3 (0.51) | RAB9ANPC1KDM2BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |